Pyridoxal Phosphate
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Pyridoxal Phosphate
Pyridoxal phosphate is a coenzyme that is concerned with amino acid metabolism. It is derived from vitamin B6 which occurs in three types of compounds, namely pyridoxine, pyridoxal, and pyridoxamine.
These are all pyridine derivatives which are widely distributed in animal and plant kingdoms. The importance of pyridoxal and other derivatives can be illustrated by the fact that rats deficient in vitamin B6 suffered from dermatitis and defects in protein metabolism. The vitamin was isolated and characterized in 1936 by Birch and Gyory.
These are all pyridine derivatives which are widely distributed in animal and plant kingdoms. The importance of pyridoxal and other derivatives can be illustrated by the fact that rats deficient in vitamin B6 suffered from dermatitis and defects in protein metabolism. The vitamin was isolated and characterized in 1936 by Birch and Gyory.
Biochemical function : The biochemical active form of pyridoxal is pyridoxal phosphate. Pyridoxine and pyridoxamine also occur as phosphate derivatives present as the coenzymes form.
Pyridoxal phosphate –dependent enzymes catalyze a variety of reaction in amino acid metabolism, such as transamination, decarboxylation reaction involve a donor and an acceptor keto acid.
Transamination :
Transamination :
Decarboxylation:
In all the above mentioned reaction, pyridoxal phosphate functions as the coenzyme, non-covalently bound as a schiff’s base to the lysine residue of the enzyme. The Schiff’s base is a common intermediate which arises from the amino acid and pyridoxal phosphate.
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