Tetrahydrofolic Acid
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Tetrahydrofolic Acid
Tetrahydrofolic acid coenzymes participate in many metabolic reactions. Folic acid is the main component, which was first obtained from green leaves. It plays an essential role in cellular metabolism, especially in the production of red cells in the bone marrow. The folic acid consists of pteroil glutamic acid in which the pteridine ring is linked to p-aminobenzoic acid joined to glutamic acid residue. The structure is as follows
Leucovorin is a folic acid derivative which is a growth factor for the bacterium Leuconostoc citrovorum. Tetrahydrofolic acid is responsible for the transfer of one carbon. Fragments at the oxidation level of formats, formaldehyde and methanol. At the level of oxidation concerning formate, the coenzyme exists in four forms: N-10-formyl FH4, N-5-formyl-FH4,N-5-formamino FH4 and N-5, N-10-methenyl FH4. These can be synthesized in various ways.Homocysteine +N-5-methionine is synthesized in the following way:
In mammals and some bacteria, cobalamin enzyme are also involved :
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